Table of Contents
MICROGRAVITY AND
BONE CELL MECHANOSENSITIVITY
--Rheological Characterization of the
Parallel-plate Flow Chamber
R.G. Bacabac
ACTA-Vrije Universiteit,
Dept Oral Cell Biology,
Amsterdam, The Netherlands
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AIM
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Loading induces shear stress
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Parallel plate flow chamber
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Fluid flow in vitro model
(for ground expts)
Microgravity experiment scheme
Experiment container
(EC type II/E) for space expts
Objective
Flow conditions
Idealized case: steady flow, infinitely wide plates
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Steady Flow
Arbitrary units
Line graphs (arbitrary units)
T = wall shear; Vx = velocity
Time dependent flow
Downscaled proto-type
(not drawn to scale)
Flow chamber in centrifuge
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Vx at y = 0.15 mm, x = 3 mm
Vx at z = 0, x = 3 mm
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Discussion
Microgravity and Bone Cell Mechanosensitivity
--Rheological Characterization of the
Parallel-plate Flow Chamber
R.G. Bacabac1,
Th.H. Smit2,
J.J.W.A. van Loon1,*,
M.J.B.M. Pourquie3,
F.T.M. Nieuwstadt3,
J. Klein-Nulend1
1 ( *DESC ), ACTA-Vrije Universiteit, Dept Oral Cell Biology, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands
2VUMC-Vrije Universiteit, Dept Clinical Physics and Informatics, Amsterdam, The Netherlands
3Delft University of Technology, Lab. Aero & Hydrodynamics, Delft, The Netherlands
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Author: Rommel G. Bacabac, AVTA-VU,
Amsterdam, NL
Email address for technical comments: j.van_loon.ocb.acta@med.vu.nl
DESC Home / Intro Page: http://www.desc.med.vu.nl/Frames.htm
Other information:
Please contact the author directly (see e-mail address on the abstract) when you have questions or remarks concerning this presentation.
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