Transcription Factor Jun/AP1 : Key Regulator in Signal Transduction and Differentiation.

Rolf de Groot
University of Utrecht, 15 May, 1991.

Promotoren: prof.dr. S.W. de Laat
Copromotor: dr. W. Kruijer

Contents:

• Prologue
  

Part A - Jun/Ap-1, EC cell differentiation and signal transduction

• Chapter A-I: Introduction.
• Chapter A-II: Differential expression of Jun and Fos genes during the lifferentiation of mouse P19 EC cells.
• Chapter A-III: Ectopic expression of c-jun Ieads to differentiation of P19 EC cells.
• Chapter A-IV: Positive regulation of Jun/AP-1 by E1A.
• Chapter A-V: Ectopic expression JunB blocks neuronal differentiation P19 EC cells.
• Chapter A-VI: Transcriptional control of c-jun by retinoic acid.
• Chapter A-VII: Transcriptional activation by TGF~ß mediated by the DSE and the TRE.
• Chapter A-VIII: Activation of junB by PKC and PKA signal transduction through a novel cis-acting element.
• Chapter A-IX: Characterization of the mouse junD promotor: High basal level activity due to an octamer motif.
• Chapter A-X: General Discussion
• Chapter A-XI: Summary
• Samenvatting

Part B - Microgravity and Immediate Early Gene Expression.

• Chapter B-I: Introduction
• Chapter B-II: EGF-induced expression of c-fos is influenced by altered gravity conditions. (full text)
• Chapter B-III: Microgravity decreases c-fos induction and serum response element activity. (full text)
• Chapter B-IV: Nuclear responses to signal transduction are sensitive to gravity changes. (full text)
• Chapter B-V: Summary and Discussion.
• Samenvatting
• Final Remarks
• Dankwoord
• Curriculum Vitae
• List of Publications